New Study Released by JAMA Psychiatry Showcases that CBD May Have Antipsychotic Effects

JAMA Psychiatry

The psychiatric research journal, JAMA Psychiatry, has just published a new CBD study. The study suggests that CDB could have positive antipsychotic effects on individuals with high-risk clinical psychosis.

JAMA Psychiatry

This study builds off compelling prior research that has demonstrated CBD’s therapeutic effects. Not only does the new study shed important light on whether or not CBD has calming cognitive effects but it also showcases how it produces them. The study is named the “Effect of Cannabidiol on Medial Temporal, Mid-brain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis.”

This small study used 52 individuals. 33 of these individuals were clinical high-risk psychosis patients, and the other 19 were healthy individuals. The study was a double-blind, randomized clinical trial. A single dose of cannabidiol was given in the striatum, medial temporal cortex, and midbrain. Others received no CBD or a placebo but were administered in the same brain regions.

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Results

The trial revealed that all three brain regions experienced modulated activations as a result of the CBD. An MRI was performed while participants conducted various verbal learning tasks, while researchers measured brain activation.

What was found was CHR patients who were given the CBD had activation levels about in the middle between the healthy individuals in the trial with no disturbances and the CHR patients that were administered the placebo.

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Overall, CBD did have the effects that the researchers had hypothesized. The oral dose of cannabidiol aided in normalizing dysfunction in all three brain regions.

These new findings have not only implications for psychiatric medicine but also on the effects of cannabis on mental health. There have been studies that have shown links between frequent and excessive cannabis use and the development of psychosis. This new research shows that CBD, a non-psychoactive cannabinoid, has an opposite neural and behavioral effect to THC. This new study now helps scientists know more about why that is.

What do you think about this new CBD study?

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